The amphipathic nature of the lipid bilayer, whose tails are hydrophobic and associate with each other and whose head groups are hydrophilic and interact with the aqueous environment, are critical to ...The amphipathic nature of the lipid bilayer, whose tails are hydrophobic and associate with each other and whose head groups are hydrophilic and interact with the aqueous environment, are critical to its structure. The composition of the lipid bilayer is also important for the diffusion both across and within the membrane. This membrane diffusion is important for a variety of functions, some of which include regulating the fluidity of the membrane, and the uptake of metabolites into the cell.