Membrane asymmetry happens when a membrane no longer resembles uniformity in terms of lipid or protein distribution and relative leaflet curvature. The degree of asymmetry covers a wide range since, t...Membrane asymmetry happens when a membrane no longer resembles uniformity in terms of lipid or protein distribution and relative leaflet curvature. The degree of asymmetry covers a wide range since, theoretically, asymmetry is any deviation of the 50:50 proportion when comparing two surfaces. Asymmetry can occur on both sides of a biological membrane or on just one (transverse asymmetry). Phase separation is one of the simplest examples of membrane asymmetry.