Amphipathic compounds (detergents) are a unique set of molecules with the ability of manipulation (distortion or formation) of the hydrophobic-hydrophilic interactions in biological samples. Detergent...Amphipathic compounds (detergents) are a unique set of molecules with the ability of manipulation (distortion or formation) of the hydrophobic-hydrophilic interactions in biological samples. Detergents in an aqueous solution self-associate to colloid particles. The formation of the colloidal aggregates by detergents are termed micelles. In research micelle-forming detergents provide an amphipathic environment that can mimic lipid bilayers.