The great problem is in understanding the meaning of virtual particles. Suppose we are studying the vacuum state in QED. We wish to describe this vacuum in terms of the states of no positrons, electro...The great problem is in understanding the meaning of virtual particles. Suppose we are studying the vacuum state in QED. We wish to describe this vacuum in terms of the states of no positrons, electrons and photons (the naive vacuum). Since these particles interact we have short-lived states where e+e− pairs, and photons, and .... appear for a short while and disappear again. This is also true for real particles.