A solution is a homogeneous mixture where one substance (the solute) is uniformly dispersed in another substance (the solvent). Solubility is the ability of a solute to dissolve in a solvent at a spec...A solution is a homogeneous mixture where one substance (the solute) is uniformly dispersed in another substance (the solvent). Solubility is the ability of a solute to dissolve in a solvent at a specific temperature and pressure. Nature of Solute and Solvent: "Like dissolves like" – polar solutes dissolve in polar solvents, and non-polar solutes dissolve in non-polar solvents.